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Erythrocytosis has been reported as a potential impact of testosterone, which might be useful in sufferers with anemia. The biggest menace of erythrocytosis occurs with injectable types of testosterone compared with transdermal preparations, especially in supraphysiologic doses. In addition, this affected person moreover had polycythemia, probably secondary to high-dose testosterone. Development of an atheromatous plaque perpetuates endothelial dysfunction and promotes platelet aggregation and intracoronary thrombus formation (Ajayi et al 1995; Nieminen et al 1996).
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Moreover, part of endothelial dysfunction has been proposed, which can contribute to irregular vessel reactivity. However, testosterone in physiologic doses would possibly even be beneficial in patients with angina , have larger ischemic thresholds and improved high quality of life . Short-term intracoronary administration of testosterone induces coronary artery dilation and can increase coronary blood move in males with established coronary artery sickness . Therefore, an interplay of endogenous components of the patient’s danger profile as properly as the testosterone dosing may be issues with whether or not adverse occasions occur. Anabolic androgenic steroid use has elevated over the previous decade, despite its potential for opposed effects.
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